Many families use Rome as the starting point for 10-14 day trips to Italy. Rome is my favorite big city in Europe with kids. The layers of history, the chaos, the loitering — it’s impossible to be an outsider here as you are always drawn into the action in some way, shape, or form.
I actually recommend spending at least 4 days in Rome (see my post on creating the best family-friendly Itinerary in Italy). However, I know how hard it is to allocate precious days on vacation and many people end up in Rome for just 72 hours.
Rome is made up of many neighborhoods and choosing where to stay—with or without kids—can be overwhelming.
The final decision should be made based on the type of experience you want to have, what you want to explore while you’re there, and the accommodation category—hotel, villa, or apartment—you choose.